Abstract

C-reactive protein (CRP) is a circulating biomarker indicative of systemic inflammation. We aimed to evaluate genetic associations with CRP levels among non-European-ancestry populations through discovery, fine-mapping and conditional analyses. A total of 30 503 non-European-ancestry participants from 6 studies participating in the Population Architecture using Genomics and Epidemiology study had serum high-sensitivity CRP measurements and ∼200 000 single nucleotide polymorphisms (SNPs) genotyped on the Metabochip. We evaluated the association between each SNP and log-transformed CRP levels using multivariate linear regression, with additive genetic models adjusted for age, sex, the first four principal components of genetic ancestry, and study-specific factors. Differential linkage disequilibrium patterns between race/ethnicity groups were used to fine-map regions associated with CRP …

Date

August 15, 2018

Authors

Jonathan M Kocarnik, Melissa Richard, Misa Graff, Jeffrey Haessler, Stephanie Bien, Chris Carlson, Cara L Carty, Alexander P Reiner, Christy L Avery, Christie M Ballantyne, Andrea Z LaCroix, Themistocles L Assimes, Maja Barbalic, Nathan Pankratz, Weihong Tang, Ran Tao, Dongquan Chen, Gregory A Talavera, Martha L Daviglus, Diana A Chirinos-Medina, Rocio Pereira, Katie Nishimura, Petra Bůžková, Lyle G Best, José Luis Ambite, Iona Cheng, Dana C Crawford, Lucia A Hindorff, Myriam Fornage, Gerardo Heiss, Kari E North, Christopher A Haiman, Ulrike Peters, Loic Le Marchand, Charles Kooperberg

Journal

Human molecular genetics

Volume

27

Issue

16

Pages

2940-2953

Publisher

Oxford University Press