Abstract

Background
High-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and triglyceride (TG) levels are influenced by both genes and the environment. Genome-wide association studies (GWAS) have identified ~100 common genetic variants associated with HDL-C, LDL-C, and/or TG levels, mostly in populations of European descent, but little is known about the modifiers of these associations. Here, we investigated whether GWAS-identified SNPs for lipid traits exhibited heterogeneity by sex in the Population Architecture using Genomics and Epidemiology (PAGE) study.
Results
A sex-stratified meta-analysis was performed for 49 GWAS-identified SNPs for fasting HDL-C, LDL-C, and ln(TG) levels among adults self-identified as European American (25,013). Heterogeneity by sex was established when phet < 0.001. There …

Date

January 1, 1970

Authors

Kira C Taylor, Cara L Carty, Logan Dumitrescu, Petra Bůžková, Shelley A Cole, Lucia Hindorff, Fred R Schumacher, Lynne R Wilkens, Ralph V Shohet, P Miguel Quibrera, Karen C Johnson, Brian E Henderson, Jeff Haessler, Nora Franceschini, Charles B Eaton, David J Duggan, Barbara Cochran, Iona Cheng, Chris S Carlson, Kristin Brown-Gentry, Garnet Anderson, Jose Luis Ambite, Christopher Haiman, Loïc Le Marchand, Charles Kooperberg, Dana C Crawford, Steven Buyske, Kari E North, Myriam Fornage, PAGE Study

Journal

BMC genetics

Volume

14

Pages

1-10

Publisher

BioMed Central