Abstract

Genome-wide association studies (GWAS) have identified many variants that influence high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and/or triglycerides. However, environmental modifiers, such as smoking, of these known genotype–phenotype associations are just recently emerging in the literature. We have tested for interactions between smoking and 49 GWAS-identified variants in over 41,000 racially/ethnically diverse samples with lipid levels from the Population Architecture Using Genomics and Epidemiology (PAGE) study. Despite their biological plausibility, we were unable to detect significant SNP × smoking interactions.

Date

January 1, 1970

Authors

Logan Dumitrescu, Cara L Carty, Nora Franceschini, Lucia A Hindorff, Shelley A Cole, Petra Bůžková, Fredrick R Schumacher, Charles B Eaton, Robert J Goodloe, David J Duggan, Jeff Haessler, Barbara Cochran, Brian E Henderson, Iona Cheng, Karen C Johnson, Chris S Carlson, Shelly-Anne Love, Kristin Brown-Gentry, Alejandro Q Nato, Miguel Quibrera, Ralph V Shohet, José Luis Ambite, Lynne R Wilkens, Loïc Le Marchand, Christopher A Haiman, Steven Buyske, Charles Kooperberg, Kari E North, Myriam Fornage, Dana C Crawford

Journal

Human genetics

Volume

132

Pages

1427-1431

Publisher

Springer Berlin Heidelberg