Abstract

Common genetic risk variants for type 2 diabetes (T2D) have primarily been identified in populations of European and Asian ancestry. We tested whether the direction of association with 20 T2D risk variants generalizes across six major racial/ethnic groups in the U.S. as part of the Population Architecture using Genomics and Epidemiology Consortium (16,235 diabetes case and 46,122 control subjects of European American, African American, Hispanic, East Asian, American Indian, and Native Hawaiian ancestry). The percentage of positive (odds ratio [OR] >1 for putative risk allele) associations ranged from 69% in American Indians to 100% in European Americans. Of the nine variants where we observed significant heterogeneity of effect by racial/ethnic group (Pheterogeneity < 0.05), eight were positively associated with risk (OR >1) in at least five groups. The marked directional consistency of …

Date

June 1, 2012

Authors

Christopher A Haiman, Megan D Fesinmeyer, Kylee L Spencer, Petra Bůžková, V Saroja Voruganti, Peggy Wan, Jeff Haessler, Nora Franceschini, Kristine R Monroe, Barbara V Howard, Rebecca D Jackson, Jose C Florez, Laurence N Kolonel, Steven Buyske, Robert J Goodloe, Simin Liu, JoAnn E Manson, James B Meigs, Kevin Waters, Kenneth J Mukamal, Sarah A Pendergrass, Peter Shrader, Lynne R Wilkens, Lucia A Hindorff, Jose Luis Ambite, Kari E North, Ulrike Peters, Dana C Crawford, Loic Le Marchand, James S Pankow

Journal

Diabetes

Volume

61

Issue

6

Pages

1642-1647

Publisher

American Diabetes Association