Abstract

The field of phenomics has been investigating network structure among large arrays of phenotypes, and genome‐wide association studies (GWAS) have been used to investigate the relationship between genetic variation and single diseases/outcomes. A novel approach has emerged combining both the exploration of phenotypic structure and genotypic variation, known as the phenome‐wide association study (PheWAS). The Population Architecture using Genomics and Epidemiology (PAGE) network is a National Human Genome Research Institute (NHGRI)‐supported collaboration of four groups accessing eight extensively characterized epidemiologic studies. The primary focus of PAGE is deep characterization of well‐replicated GWAS variants and their relationships to various phenotypes and traits in diverse epidemiologic studies that include European Americans, African Americans, Mexican Americans …

Date

July 1, 2011

Authors

SA Pendergrass, K Brown‐Gentry, SM Dudek, ES Torstenson, JL Ambite, CL Avery, S Buyske, C Cai, MD Fesinmeyer, C Haiman, G Heiss, LA Hindorff, C‐N Hsu, RD Jackson, C Kooperberg, L Le Marchand, Y Lin, TC Matise, L Moreland, K Monroe, AP Reiner, R Wallace, LR Wilkens, DC Crawford, MD Ritchie

Journal

Genetic epidemiology

Publisher

Wiley Subscription Services, Inc., A Wiley Company